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10.1091/mbc.E14-09-1413 http://scihub22266oqcxt.onion/10.1091/mbc.E14-09-1413 C4454184!4454184 !25631822     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25631822 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25631822 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Biol+Cell 2015 ; 26 (7 ): 1395-410 Nephropedia Template TP {{tp|p=25631822 |t=2015. Heterochromatin formation via recruitment of DNA repair proteins |pdf=|usr=}}{{25631822 }} gab.com Text Heterochromatin formation via recruitment of DNA repair proteins JO: Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25631822 #FOAvip Heterochromatin formation and nuclear organization are important in gene regulation and genome fidelity. Proteins involved in gene silencing localize to sites of damage and some DNA repair proteins localize to heterochromatin, but the biological importance of these correlations remains unclear. In this study, we examined the role of double-strand-break repair proteins in gene silencing and nuclear organization. We find that the ATM kinase Tel1 and the proteins Mre11 and Esc2 can silence a reporter gene dependent on the Sir, as well as on other repair proteins. Furthermore, these proteins aid in the localization of silenced domains to specific compartments in the nucleus. We identify two distinct mechanisms for repair protein-mediated silencing-via direct and indirect interactions with Sir proteins, as well as by tethering loci to the nuclear periphery. This study reveals previously unknown interactions between repair proteins and silencing proteins and suggests insights into the mechanism underlying genome integrity. Twit Text FOAVip Heterochromatin formation via recruitment of DNA repair proteins ????Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25631822 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25631822 #FOAvip English Wikipedia <ref>{{Cite pmid|25631822 }}</ref> Heterochromatin formation via recruitment of DNA repair proteins #MMPMID25631822 Kirkland JG ; Peterson MR ; Still CD 2nd ; Brueggeman L ; Dhillon N ; Kamakaka RT Mol Biol Cell 2015[Apr]; 26 (7 ): 1395-410 PMID25631822 show ga Heterochromatin formation and nuclear organization are important in gene regulation and genome fidelity. Proteins involved in gene silencing localize to sites of damage and some DNA repair proteins localize to heterochromatin, but the biological importance of these correlations remains unclear. In this study, we examined the role of double-strand-break repair proteins in gene silencing and nuclear organization. We find that the ATM kinase Tel1 and the proteins Mre11 and Esc2 can silence a reporter gene dependent on the Sir, as well as on other repair proteins. Furthermore, these proteins aid in the localization of silenced domains to specific compartments in the nucleus. We identify two distinct mechanisms for repair protein-mediated silencing-via direct and indirect interactions with Sir proteins, as well as by tethering loci to the nuclear periphery. This study reveals previously unknown interactions between repair proteins and silencing proteins and suggests insights into the mechanism underlying genome integrity. |*Chromatin Assembly and Disassembly [MESH] |*DNA Repair [MESH] |Cell Cycle Proteins [MESH] |Cell Nucleus/metabolism [MESH] |Chromosomes, Fungal/*metabolism [MESH] |Endodeoxyribonucleases/metabolism [MESH] |Exodeoxyribonucleases/metabolism [MESH] |Gene Silencing [MESH] |Heterochromatin/*metabolism [MESH] |Intracellular Signaling Peptides and Proteins/metabolism [MESH] |Nuclear Proteins/metabolism [MESH] |Protein Serine-Threonine Kinases/metabolism [MESH] |Saccharomyces cerevisiae Proteins/metabolism [MESH] |Saccharomyces cerevisiae/*genetics/metabolism [MESH]Heterochromatin formation via recruitment of DNA repair proteins (epmc).pdf DeepDyve Pubget Overpricing