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2015 ; 35
(3
): ä Nephropedia Template TP
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Hepcidin: regulation of the master iron regulator
#MMPMID26182354
Rishi G
; Wallace DF
; Subramaniam VN
Biosci Rep
2015[Mar]; 35
(3
): ä PMID26182354
show ga
Iron, an essential nutrient, is required for many diverse biological processes.
The absence of a defined pathway to excrete excess iron makes it essential for
the body to regulate the amount of iron absorbed; a deficiency could lead to iron
deficiency and an excess to iron overload and associated disorders such as
anaemia and haemochromatosis respectively. This regulation is mediated by the
iron-regulatory hormone hepcidin. Hepcidin binds to the only known iron export
protein, ferroportin (FPN), inducing its internalization and degradation, thus
limiting the amount of iron released into the blood. The major factors that are
implicated in hepcidin regulation include iron stores, hypoxia, inflammation and
erythropoiesis. The present review summarizes our present knowledge about the
molecular mechanisms and signalling pathways contributing to hepcidin regulation
by these factors.
|Animals
[MESH]
|Bone Morphogenetic Proteins/*metabolism
[MESH]
|Cation Transport Proteins/genetics/metabolism
[MESH]
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