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2015 ; 4
(4
): 313-22
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Hepatitis delta virus: A fascinating and neglected pathogen
#MMPMID26568914
Cunha C
; Tavanez JP
; Gudima S
World J Virol
2015[Nov]; 4
(4
): 313-22
PMID26568914
show ga
Hepatitis delta virus (HDV) is the etiologic agent of the most severe form of
virus hepatitis in humans. Sharing some structural and functional properties with
plant viroids, the HDV RNA contains a single open reading frame coding for the
only virus protein, the Delta antigen. A number of unique features, including
ribozyme activity, RNA editing, rolling-circle RNA replication, and redirection
for a RNA template of host DNA-dependent RNA polymerase II, make this small
pathogen an excellent model to study virus-cell interactions and RNA biology.
Treatment options for chronic hepatitis Delta are scarce and ineffective. The
disease burden is perhaps largely underestimated making the search for new,
specific drugs, targets, and treatment strategies an important public health
challenge. In this review we address the main features of virus structure,
replication, and interaction with the host. Virus pathogenicity and current
treatment options are discussed in the light of recent developments.