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2015 ; 5
(Suppl 1
): S4-6
Nephropedia Template TP
J Clin Exp Hepatol
2015[Mar]; 5
(Suppl 1
): S4-6
PMID26041956
show ga
The history of hepatic encephalopathy (HE) is briefly reviewed since the
beginning of western medicine by Hippocrates. For about 2000 years the main
evidence was the mere association between jaundice, fever and delirium. A clear
link between delirium and cirrhosis was proven in the 17th century by Morgagni.
In subsequent times the focus was manly the descriptions of symptoms and the only
pathophysiological improvement was the evidence that jaundice, per se, does not
alter brain function. Only at the end of the 19th century Hann et al proved the
role of portal-systemic shunt and pf nitrogenous derivates in the pathophysiology
of the syndrome. A terrific development of knowledge occurred in the last 60
years, after the works of Sherlock in London. Nowadays some consensus about HE
was reached, so that new developments will likely occur.
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