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2015 ; 5
(7
): a021386
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Hepadnavirus Genome Replication and Persistence
#MMPMID26134841
Hu J
; Seeger C
Cold Spring Harb Perspect Med
2015[Jul]; 5
(7
): a021386
PMID26134841
show ga
Hallmarks of the hepadnavirus replication cycle are the formation of covalently
closed circular DNA (cccDNA) and the reverse transcription of a pregenomic RNA
(pgRNA) in core particles leading to synthesis of the relaxed circular DNA
(rcDNA) genome. cccDNA, the template for viral RNA transcription, is the basis
for the persistence of these viruses in infected hepatocytes. In this review, we
summarize the current state of knowledge on the mechanisms of hepadnavirus
reverse transcription and the biochemical and structural properties of the viral
reverse transcriptase (RT). We highlight important gaps in knowledge regarding
cccDNA biosynthesis and stability. In addition, we discuss the impact of current
antiviral therapies on viral persistence, particularly on cccDNA.
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