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2017 ; 11
(1
): 1-7
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Hemophagocytic histiocytosis: A Clinicopathological correlation
#MMPMID28293160
Iqbal W
; Alsalloom AA
; Shehzad K
; Mughal F
; Rasheed Z
Int J Health Sci (Qassim)
2017[Jan]; 11
(1
): 1-7
PMID28293160
show ga
OBJECTIVES: Histiocytic hyperplasia with hemophagocytosis (HP) is relatively
uncommon condition that has often been mistaken in the past for neoplastic
disorders. This study was conducted to investigate the possible etiology of HP,
its intensity in the bone marrow (BM), and also its effect on hematological
parameters with the extent of disease activity. METHODS: Blood samples were
collected and BM examination was performed in 250 patients with varied etiology
showing HP. Complete blood counts, reticulocyte count, and red blood cell
morphology were determined. HP was examined in the BM smears by Leishman
staining. The severity of HP was determined by grading of its intensity in the BM
smears. RESULTS: Our data showed variable degree of HP (mild, moderate, and
severe) in the BM smears of patients having different underlying disorders. HP
syndrome (HPS) with clinical and biochemical derangements was found in 24 (9.6%)
patients. HPS was mostly associated with infection. The etiological distribution
in different group of disorders was nonmalignant hematological conditions
(56.80%), infections (24.80%), storage disorders (4.40%), malignant hematological
conditions (4.40%), autoimmune disorders (1.20%), and miscellaneous group
(8.40%). Distribution of patients in different grades of intensity of HP was
Grade I (35.50%; mild), Grade II (45.50%; moderate), and Grade III (19.60%;
severe). CONCLUSION: We conclude that severe degree of HP has profound effect on
hematological parameters particularly hemoglobin and platelet counts. This
phenomenon may present as HPS with fatal outcome. We also conclude that there was
no effect of age on either intensity of HP or on blood counts.
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