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2017 ; 6
(2
): 135-139
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Hemolytic uremic syndrome in adults: A case report
#MMPMID28529915
Pérez-Cruz FG
; Villa-Díaz P
; Pintado-Delgado MC
; Fernández Rodríguez ML
; Blasco-Martínez A
; Pérez-Fernández M
World J Crit Care Med
2017[May]; 6
(2
): 135-139
PMID28529915
show ga
Thrombotic microangiopathies (TMA) are microvascular occlusive disorders
characterized by platelet aggregation and mechanical damage to erythrocytes,
clinically characterized by microangiopatic haemolytic anemia, thrombocytopenia
and organ injury. We are reporting a case of a woman patient with severe
hemolytic uremic syndrome associated to infectious diarrhoea caused by Shiga
toxin-producing pathogen, who were admitted to our intensive care unit. The
patient described developed as organ injury, neurological failure and acute renal
failure, with need of haemodialysis technique. Due to the severity of the case
and the delay in the results of the additional test that help us to the final
diagnose, we treated her based on a syndromic approach of TMA with plasma
exchange, with favourable clinical evolution with complete recovery of organ
failures. We focus on the syndromic approach of these diseases, because
thrombotic thrombocytopenic purpura, one of the disorders that are included in
the syndromes of TMA, is considered a haematological urgency given their high
mortality without treatment; and also review the TMA in adults: Their
pathogenesis, management and outcomes.