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2016 ; 25
(3
): 165-83
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Heme Oxygenase-1 in Kidney Health and Disease
#MMPMID26906116
Lever JM
; Boddu R
; George JF
; Agarwal A
Antioxid Redox Signal
2016[Jul]; 25
(3
): 165-83
PMID26906116
show ga
SIGNIFICANCE: Acute kidney injury (AKI) and chronic kidney disease (CKD)
represent a considerable burden in healthcare. The heme oxygenase (HO) system
plays an important role in regulating oxidative stress and is protective in a
variety of human and animal models of kidney disease. Preclinical studies of the
HO system have led to the development of several clinical trials targeting the
enzyme or its products. RECENT ADVANCES: Connection of HO, ferritin, and other
proteins involved in iron regulation has provided important insight into
mechanisms of damage in AKI. Also, HO-1 expression is important in the
pathogenesis of hypertension, diabetic kidney disease, and progression to
end-stage renal disease. CRITICAL ISSUES: Despite intriguing discoveries, no
drugs targeting the HO system have been translated to the clinic. Meanwhile,
treatments for AKI and CKD are urgently needed. Many factors have likely
contributed to challenges in clinical translation, including variation in animal
models, difficulties in obtaining human tissue, and complexity of the disease
processes being studied. FUTURE DIRECTIONS: The HO system represents a promising
avenue of investigation that may lead to targeted therapeutics. Tissue-specific
gene modulation, widening the scope of animal studies, and continued clinical
research will provide valuable insight into the role HO plays in kidney
homeostasis and disease. Antioxid. Redox Signal. 25, 165-183.
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