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2013 ; 140
(12
): 2463-7
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Hematopoiesis
#MMPMID23715539
Jagannathan-Bogdan M
; Zon LI
Development
2013[Jun]; 140
(12
): 2463-7
PMID23715539
show ga
Hematopoiesis - the process by which blood cells are formed - has been studied
intensely for over a century using a variety of model systems. There is
conservation of the overall hematopoietic process between vertebrates, although
some differences do exist. Over the last decade, the zebrafish has come to the
forefront as a new model in hematopoiesis research, as it allows the use of
large-scale genetics, chemical screens and transgenics. This comparative approach
to understanding hematopoiesis has led to fundamental knowledge about the process
and to the development of new therapies for disease. Here, we provide a broad
overview of vertebrate hematopoiesis. We also highlight the benefits of using
zebrafish as a model.
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