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2018 ; 19
(3
): ä Nephropedia Template TP
gab.com Text
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Hazard Screening Methods for Nanomaterials: A Comparative Study
#MMPMID29495342
Sheehan B
; Murphy F
; Mullins M
; Furxhi I
; Costa AL
; Simeone FC
; Mantecca P
Int J Mol Sci
2018[Feb]; 19
(3
): ä PMID29495342
show ga
Hazard identification is the key step in risk assessment and management of
manufactured nanomaterials (NM). However, the rapid commercialisation of
nano-enabled products continues to out-pace the development of a prudent risk
management mechanism that is widely accepted by the scientific community and
enforced by regulators. However, a growing body of academic literature is
developing promising quantitative methods. Two approaches have gained significant
currency. Bayesian networks (BN) are a probabilistic, machine learning approach
while the weight of evidence (WoE) statistical framework is based on expert
elicitation. This comparative study investigates the efficacy of quantitative WoE
and Bayesian methodologies in ranking the potential hazard of metal and
metal-oxide NMs-TiO?, Ag, and ZnO. This research finds that hazard ranking is
consistent for both risk assessment approaches. The BN and WoE models both
utilize physico-chemical, toxicological, and study type data to infer the hazard
potential. The BN exhibits more stability when the models are perturbed with new
data. The BN has the significant advantage of self-learning with new data;
however, this assumes all input data is equally valid. This research finds that a
combination of WoE that would rank input data along with the BN is the optimal
hazard assessment framework.