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10.1155/2015/368736

http://scihub22266oqcxt.onion/10.1155/2015/368736
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C4458560!4458560 !26101781
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suck abstract from ncbi


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pmid26101781
      J+Immunol+Res 2015 ; 2015 (ä): 368736
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  • Harnessing the Microbiome to Enhance Cancer Immunotherapy #MMPMID26101781
  • Nelson MH ; Diven MA ; Huff LW ; Paulos CM
  • J Immunol Res 2015[]; 2015 (ä): 368736 PMID26101781 show ga
  • The microbiota plays a key role in regulating the innate and adaptive immune system. Herein, we review the immunological aspects of the microbiota in tumor immunity in mice and man, with a focus on toll-like receptor (TLR) agonists, vaccines, checkpoint modulators, chemotherapy, and adoptive T cell transfer (ACT) therapies. We propose innovative treatments that may safely harness the microbiota to enhance T cell-based therapies in cancer patients. Finally, we highlight recent developments in tumor immunotherapy, particularly novel ways to modulate the microbiome and memory T cell responses to human malignancies.
  • |*Immunotherapy/methods [MESH]
  • |Adaptive Immunity [MESH]
  • |Animals [MESH]
  • |Bacterial Toxins/immunology [MESH]
  • |Cancer Vaccines/immunology [MESH]
  • |Chemotherapy, Adjuvant [MESH]
  • |Cytokines/metabolism [MESH]
  • |Gastrointestinal Microbiome [MESH]
  • |Gene Expression Regulation, Neoplastic [MESH]
  • |Humans [MESH]
  • |Immunity, Innate [MESH]
  • |Immunomodulation [MESH]
  • |Immunotherapy, Adoptive [MESH]
  • |Lymphocyte Depletion [MESH]
  • |Microbiota/drug effects/*immunology [MESH]
  • |Neoplasms/genetics/*immunology/metabolism/pathology/*therapy [MESH]
  • |T-Lymphocytes/immunology/metabolism [MESH]
  • |Toll-Like Receptors/genetics/metabolism [MESH]


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