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2015 ; 2015
(ä): 368736
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Harnessing the Microbiome to Enhance Cancer Immunotherapy
#MMPMID26101781
Nelson MH
; Diven MA
; Huff LW
; Paulos CM
J Immunol Res
2015[]; 2015
(ä): 368736
PMID26101781
show ga
The microbiota plays a key role in regulating the innate and adaptive immune
system. Herein, we review the immunological aspects of the microbiota in tumor
immunity in mice and man, with a focus on toll-like receptor (TLR) agonists,
vaccines, checkpoint modulators, chemotherapy, and adoptive T cell transfer (ACT)
therapies. We propose innovative treatments that may safely harness the
microbiota to enhance T cell-based therapies in cancer patients. Finally, we
highlight recent developments in tumor immunotherapy, particularly novel ways to
modulate the microbiome and memory T cell responses to human malignancies.