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2015 ; 36
(24
): 1512-8
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Haeme oxygenase signalling pathway: implications for cardiovascular disease
#MMPMID25827602
Fredenburgh LE
; Merz AA
; Cheng S
Eur Heart J
2015[Jun]; 36
(24
): 1512-8
PMID25827602
show ga
Evidence now points to the haeme oxygenase (HO) pathway as a possible actor in
modulating risk for cardiovascular disease (CVD). In particular, the HO pathway
may represent a key endogenous modulator of oxidative, inflammatory, and
cytotoxic stress while also exhibiting vasoregulatory properties. In this review,
we summarize the accumulating experimental and emerging clinical data indicating
how activity of the HO pathway and its products may play a role in mechanisms
underlying the development of CVD. We also identify gaps in the literature to
date and suggest future directions for investigation. Because HO pathway activity
can be influenced not only by genetic traits and environmental stimuli but also
by a variety of existing pharmacologic interventions, the pathway could serve as
a prime target for reducing the overall burden of CVD. Further work is needed to
determine the role of HO pathway products as possible prognostic markers of risk
for clinical CVD events and the extent to which therapeutic augmentation or
inhibition of HO pathway activity could serve to modify CVD risk.
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