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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Oncotarget
2015 ; 6
(10
): 8353-65
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HOTAIR is a therapeutic target in glioblastoma
#MMPMID25823657
Zhou X
; Ren Y
; Zhang J
; Zhang C
; Zhang K
; Han L
; Kong L
; Wei J
; Chen L
; Yang J
; Wang Q
; Zhang J
; Yang Y
; Jiang T
; Li M
; Kang C
Oncotarget
2015[Apr]; 6
(10
): 8353-65
PMID25823657
show ga
HOTAIR is a negative prognostic factor and is overexpressed in multiple human
cancers including glioblastoma multiform (GBM). Survival analysis of Chinese
Glioma Genome Atlas (CGGA) patient data indicated that high HOTAIR expression was
associated with poor outcome in GBM patients. NLK (Nemo-like kinase), a negative
regulator of the ?-catenin pathway, was negatively correlated with HOTAIR
expression. When the ?-catenin pathway was inhibited, GBM cells became
susceptible to cell cycle arrest and inhibition of invasion. Introduction of the
HOTAIR 5' domain in human glioma-derived astrocytoma induced ?-catenin. An
intracranial animal model was used to confirm that HOTAIR depletion inhibited GBM
cell migration/invasion. In the orthotopic model, HOTAIR was required for GBM
formation in vivo. In summary, HOTAIR is a potential therapeutic target in GBM.
|Adult
[MESH]
|Animals
[MESH]
|Brain Neoplasms/metabolism/*therapy
[MESH]
|Cell Line, Tumor
[MESH]
|Cell Movement
[MESH]
|Cell Proliferation
[MESH]
|Glioblastoma/metabolism/*therapy
[MESH]
|Humans
[MESH]
|MCF-7 Cells
[MESH]
|Mice
[MESH]
|Middle Aged
[MESH]
|Molecular Targeted Therapy
[MESH]
|Prognosis
[MESH]
|RNA, Long Noncoding/biosynthesis/genetics/*metabolism
[MESH]
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