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10.1158/2326-6066.CIR-13-0227 http://scihub22266oqcxt.onion/10.1158/2326-6066.CIR-13-0227 C4049249!4049249 !24894089     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24894089 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24894089 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Immunol+Res 2014 ; 2 (6 ): 522-9 Nephropedia Template TP {{tp|p=24894089 |t=2014. HLA-binding properties of tumor neoepitopes in humans |pdf=|usr=}}{{24894089 }} gab.com Text HLA-binding properties of tumor neoepitopes in humans JO: Cancer Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=24894089 #FOAvip Cancer genome sequencing has enabled the rapid identification of the complete repertoire of coding sequence mutations within a patient's tumor and facilitated their use as personalized immunogens. Although a variety of techniques are available to assist in the selection of mutation-defined epitopes to be included within the tumor vaccine, the ability of the peptide to bind to patient MHC is a key gateway to peptide presentation. With advances in the accuracy of predictive algorithms for MHC class I binding, choosing epitopes on the basis of predicted affinity provides a rapid and unbiased approach to epitope prioritization. We show herein the retrospective application of a prediction algorithm to a large set of bona fide T cell-defined mutated human tumor antigens that induced immune responses, most of which were associated with tumor regression or long-term disease stability. The results support the application of this approach for epitope selection and reveal informative features of these naturally occurring epitopes to aid in epitope prioritization for use in tumor vaccines. Twit Text FOAVip HLA-binding properties of tumor neoepitopes in humans ????Cancer Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=24894089 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24894089 #FOAvip English Wikipedia <ref>{{Cite pmid|24894089 }}</ref> HLA-binding properties of tumor neoepitopes in humans #MMPMID24894089 Fritsch EF ; Rajasagi M ; Ott PA ; Brusic V ; Hacohen N ; Wu CJ Cancer Immunol Res 2014[Jun]; 2 (6 ): 522-9 PMID24894089 show ga Cancer genome sequencing has enabled the rapid identification of the complete repertoire of coding sequence mutations within a patient's tumor and facilitated their use as personalized immunogens. Although a variety of techniques are available to assist in the selection of mutation-defined epitopes to be included within the tumor vaccine, the ability of the peptide to bind to patient MHC is a key gateway to peptide presentation. With advances in the accuracy of predictive algorithms for MHC class I binding, choosing epitopes on the basis of predicted affinity provides a rapid and unbiased approach to epitope prioritization. We show herein the retrospective application of a prediction algorithm to a large set of bona fide T cell-defined mutated human tumor antigens that induced immune responses, most of which were associated with tumor regression or long-term disease stability. The results support the application of this approach for epitope selection and reveal informative features of these naturally occurring epitopes to aid in epitope prioritization for use in tumor vaccines. |Algorithms [MESH] |Antigens, Neoplasm/*genetics/immunology [MESH] |Cancer Vaccines/immunology [MESH] |Epitopes, T-Lymphocyte/genetics/*metabolism [MESH] |Histocompatibility Antigens Class I/*metabolism [MESH] |Humans [MESH] |Immunity, Cellular/genetics/immunology [MESH] |Mutation, Missense/genetics/immunology [MESH] |Neoplasms/genetics/*immunology [MESH]HLA-binding properties of tumor neoepitopes in humans (epmc).pdf DeepDyve Pubget Overpricing