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10.1007/s40265-013-0059-6 http://scihub22266oqcxt.onion/10.1007/s40265-013-0059-6 C3735343!3735343 !23733447     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23733447 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Drugs 2013 ; 73 (9 ): 893-905 Nephropedia Template TP {{tp|p=23733447 |t=2013. HIV-associated neurocognitive disorders: perspective on management strategies |pdf=|usr=}}{{23733447 }} gab.com Text HIV-associated neurocognitive disorders: perspective on management strategies JO: Drugs http://www.kidney.de/pget.php?&tw=1&pmid=23733447 #FOAvip Potent combination antiretroviral therapy (ART) has resulted in dramatic improvements in AIDS-associated morbidity and mortality. Although combination ART has resulted in a significant reduction in HIV-associated dementia, the most severe of the HIV-associated neurocognitive disorders (HAND), the overall prevalence of HAND among this population is estimated at 40%. It has been recognized that the central nervous system (CNS) serves as a reservoir for HIV, and neuronal damage begins at the time of acute infection and persists due to chronic infection of microglial and perivascular macrophages. Although combination ART has resulted in virologic control in the plasma compartment, virologic breakthrough can potentially ensue within the CNS compartment due to limited ART drug exposure. The purpose of this review is to discuss the definition, clinical spectrum, and risk factors associated with HAND, review the pathogenesis of HAND, and address the pharmacologic challenges associated with ART drug exposure in the CNS compartment. Twit Text FOAVip HIV-associated neurocognitive disorders: perspective on management strategies ????Drugs http://www.kidney.de/pget.php?&tw=1&pmid=23733447 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23733447 #FOAvip English Wikipedia <ref>{{Cite pmid|23733447 }}</ref> HIV-associated neurocognitive disorders: perspective on management strategies #MMPMID23733447 Nabha L ; Duong L ; Timpone J Drugs 2013[Jun]; 73 (9 ): 893-905 PMID23733447 show ga Potent combination antiretroviral therapy (ART) has resulted in dramatic improvements in AIDS-associated morbidity and mortality. Although combination ART has resulted in a significant reduction in HIV-associated dementia, the most severe of the HIV-associated neurocognitive disorders (HAND), the overall prevalence of HAND among this population is estimated at 40%. It has been recognized that the central nervous system (CNS) serves as a reservoir for HIV, and neuronal damage begins at the time of acute infection and persists due to chronic infection of microglial and perivascular macrophages. Although combination ART has resulted in virologic control in the plasma compartment, virologic breakthrough can potentially ensue within the CNS compartment due to limited ART drug exposure. The purpose of this review is to discuss the definition, clinical spectrum, and risk factors associated with HAND, review the pathogenesis of HAND, and address the pharmacologic challenges associated with ART drug exposure in the CNS compartment. |*HIV [MESH] |AIDS Dementia Complex/*drug therapy/*virology [MESH] |Animals [MESH] |Anti-HIV Agents/*therapeutic use [MESH] |Antiretroviral Therapy, Highly Active/methods [MESH] |HIV Infections/*complications/*drug therapy/virology [MESH] |Humans [MESH]HIV-associated neurocognitive disorders: perspective on management str(epmc).pdf DeepDyve Pubget Overpricing