Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28757894
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Future+Virol
2016 ; 11
(12
): 785-794
Nephropedia Template TP
Future Virol
2016[Dec]; 11
(12
): 785-794
PMID28757894
show ga
More than 35 million people remain infected with HIV-1. Upon antiretroviral
therapy cessation, HIV-1-positive individuals systematically fail to achieve
sustained virological remission, revealing the presence of a reservoir. This
reservoir takes into account anatomical sanctuaries where HIV-1 continues to
replicate, and latently infected cells also known as the latent reservoir (LR). A
better understanding of the nature and features of the LR and its quantification
are crucial to evaluate the efficiency of therapeutic strategies aiming at
purging HIV-1. Culture- and PCR-based assays have already been implemented to
measure the LR, and new assays are continuously being developed. In this review,
we will discuss these methods highlighting the difficulties to accurately measure
the LR, one main obstacle in curing HIV-1.