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2016 ; 24
(5
): 345-355
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HIV-1 Reservoirs During Suppressive Therapy
#MMPMID26875617
Barton K
; Winckelmann A
; Palmer S
Trends Microbiol
2016[May]; 24
(5
): 345-355
PMID26875617
show ga
The introduction of antiretroviral therapy (ART) 20 years ago has dramatically
reduced morbidity and mortality associated with HIV-1. Initially there was hope
that ART would be curative, but it quickly became clear that even though ART was
able to restore CD4(+) T cell counts and suppress viral loads below levels of
detection, discontinuation of treatment resulted in a rapid rebound of infection.
This is due to persistence of a small reservoir of latently infected cells with a
long half-life, which necessitates life-long ART. Over the past few years,
significant progress has been made in defining and characterizing the latent
reservoir of HIV-1, and here we review how understanding the latent reservoir
during suppressive therapy will lead to significant advances in curative
approaches for HIV-1.
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