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10.1080/23723556.2015.1030537

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suck abstract from ncbi

pmid27308509
      Mol+Cell+Oncol 2015 ; 2 (4 ): e1030537
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  • HIGD1A-mediated dormancy and tumor survival #MMPMID27308509
  • Ameri K ; Maltepe E
  • Mol Cell Oncol 2015[Oct]; 2 (4 ): e1030537 PMID27308509 show ga
  • Solid tumors contain regions of anoxia that are also glucose deprived. How cancer cells survive such extreme conditions remains unclear. Here, we discuss our recent findings that regulation of hypoxia inducible gene domain family member 1 A (HIGD1A) via epigenetic mechanisms during glucose starvation modulates oxygen consumption and reactive oxygen species production to enable tumor cell survival through the activation of dormancy mechanisms.
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