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2015 ; 117
(1
): 65-79
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HIF hydroxylase pathways in cardiovascular physiology and medicine
#MMPMID26089364
Bishop T
; Ratcliffe PJ
Circ Res
2015[Jun]; 117
(1
): 65-79
PMID26089364
show ga
Hypoxia inducible factors (HIFs) are ?/? heterodimeric transcription factors that
direct multiple cellular and systemic responses in response to changes in oxygen
availability. The oxygen sensitive signal is generated by a series of iron and
2-oxoglutarate-dependent dioxygenases that catalyze post-translational
hydroxylation of specific prolyl and asparaginyl residues in HIF? subunits and
thereby promote their destruction and inactivation in the presence of oxygen. In
hypoxia, these processes are suppressed allowing HIF to activate a massive
transcriptional cascade. Elucidation of these pathways has opened several new
fields of cardiovascular research. Here, we review the role of HIF hydroxylase
pathways in cardiac development and in cardiovascular control. We also consider
the current status, opportunities, and challenges of therapeutic modulation of
HIF hydroxylases in the therapy of cardiovascular disease.
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