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2015 ; 2015
(ä): bav051
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HCSD: the human cancer secretome database
#MMPMID26078477
Feizi A
; Banaei-Esfahani A
; Nielsen J
Database (Oxford)
2015[]; 2015
(ä): bav051
PMID26078477
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The human cancer secretome database (HCSD) is a comprehensive database for human
cancer secretome data. The cancer secretome describes proteins secreted by cancer
cells and structuring information about the cancer secretome will enable further
analysis of how this is related with tumor biology. The secreted proteins from
cancer cells are believed to play a deterministic role in cancer progression and
therefore may be the key to find novel therapeutic targets and biomarkers for
many cancers. Consequently, huge data on cancer secretome have been generated in
recent years and the lack of a coherent database is limiting the ability to query
the increasing community knowledge. We therefore developed the Human Cancer
Secretome Database (HCSD) to fulfil this gap. HCSD contains >80 000 measurements
for about 7000 nonredundant human proteins collected from up to 35
high-throughput studies on 17 cancer types. It has a simple and user friendly
query system for basic and advanced search based on gene name, cancer type and
data type as the three main query options. The results are visualized in an
explicit and interactive manner. An example of a result page includes
annotations, cross references, cancer secretome data and secretory features for
each identified protein.
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