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10.1126/science.1125548 http://scihub22266oqcxt.onion/10.1126/science.1125548 16556800!ä!16556800 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\16556800.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Science 2006 ; 312 (5772): 399 Nephropedia Template TP {{tp|p=16556800|t=2006. H5N1 Virus Attachment to Lower Respiratory Tract |pdf=|usr=}}{{16556800}} gab.com Text H5N1 Virus Attachment to Lower Respiratory Tract JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=16556800 #FOAvip Highly pathogenic avian influenza virus (H5N1) may cause severe lower respiratory tract (LRT) disease in humans. However, the LRT cells to which the virus attaches are unknown for both humans and other mammals. We show here that H5N1 virus attached predominantly to type II pneumocytes, alveolar macrophages, and nonciliated bronchiolar cells in the human LRT, and this pattern was most closely mirrored in cat and ferret tissues. These findings may explain, at least in part, the localization and severity of H5N1 viral pneumonia in humans. They also identify the cat and the ferret as suitable experimental animals based on this criterion. Twit Text FOAVip H5N1 Virus Attachment to Lower Respiratory Tract ????Science http://www.kidney.de/pget.php?&tw=1&pmid=16556800 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16556800 #FOAvip English Wikipedia <ref>{{Cite pmid|16556800}}</ref> H5N1 Virus Attachment to Lower Respiratory Tract #MMPMID16556800 van Riel D; Munster VJ; de Wit E; Rimmelzwaan GF; Fouchier RA; Osterhaus AD; Kuiken T Science 2006[Apr]; 312 (5772): 399 PMID16556800show ga Highly pathogenic avian influenza virus (H5N1) may cause severe lower respiratory tract (LRT) disease in humans. However, the LRT cells to which the virus attaches are unknown for both humans and other mammals. We show here that H5N1 virus attached predominantly to type II pneumocytes, alveolar macrophages, and nonciliated bronchiolar cells in the human LRT, and this pattern was most closely mirrored in cat and ferret tissues. These findings may explain, at least in part, the localization and severity of H5N1 viral pneumonia in humans. They also identify the cat and the ferret as suitable experimental animals based on this criterion. |Animals[MESH] |Bronchi/cytology/*virology[MESH] |Cats[MESH] |Disease Models, Animal[MESH] |Epithelial Cells/virology[MESH] |Ferrets[MESH] |Humans[MESH] |Influenza A Virus, H5N1 Subtype/metabolism/*pathogenicity[MESH] |Influenza, Human/virology[MESH] |Macaca[MESH] |Macrophages, Alveolar/*virology[MESH] |Mice[MESH] |Orthomyxoviridae Infections/virology[MESH] |Pneumonia, Viral/virology[MESH] |Pulmonary Alveoli/cytology/*virology[MESH] |Receptors, Virus/metabolism[MESH] |Respiratory Mucosa/*virology[MESH] |Species Specificity[MESH]H5N1 Virus Attachment to Lower Respiratory Tract (epmc).pdf DeepDyve Pubget Overpricing