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2018 ; 22
(1
): 117
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Gut-kidney crosstalk in septic acute kidney injury
#MMPMID29724256
Zhang J
; Ankawi G
; Sun J
; Digvijay K
; Yin Y
; Rosner MH
; Ronco C
Crit Care
2018[May]; 22
(1
): 117
PMID29724256
show ga
Sepsis is the leading cause of acute kidney injury (AKI) in the intensive care
unit (ICU). Septic AKI is a complex and multifactorial process that is
incompletely understood. During sepsis, the disruption of the mucus membrane
barrier, a shift in intestinal microbial flora, and microbial translocation may
lead to systemic inflammation, which further alters host immune and metabolic
homeostasis. This altered homeostasis may promote and potentiate the development
of AKI. As part of this vicious cycle, when AKI develops, the clearance of
inflammatory mediators and metabolic products is decreased. This will lead to
further gut injury and breakdown in mucous membrane barriers. Thus, changes in
the gut during sepsis can initiate and propagate septic AKI. This deleterious
gut-kidney crosstalk may be a potential target for therapeutic maneuvers. This
review analyses the underlying mechanisms in gut-kidney crosstalk in septic AKI.
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