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Gut microbiome and kidney disease: a bidirectional relationship
#MMPMID27129691
Al Khodor S
; Shatat IF
Pediatr Nephrol
2017[Jun]; 32
(6
): 921-931
PMID27129691
show ga
Recent technological advances and efforts, including powerful metagenomic and
metatranscriptomic analyses, have led to a tremendous growth in our understanding
of microbial communities. Changes in microbial abundance or composition of human
microbial communities impact human health or disease state. However, explorations
into the mechanisms underlying host-microbe interactions in health and disease
are still in their infancy. Although changes in the gut microbiota have been
described in patients with kidney disease, the relationships between
pathogenesis, mechanisms of disease progression, and the gut microbiome are still
evolving. Here, we review changes in the host-microbiome symbiotic relationship
in an attempt to explore the bidirectional relationship in which alterations in
the microbiome affect kidney disease progression and how kidney disease may
disrupt a balanced microbiome. We also discuss potential targeted interventions
that may help re-establish this symbiosis and propose more effective ways to
deploy traditional treatments in patients with kidney disease.
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