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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Hypertension
2015 ; 65
(6
): 1331-40
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Gut dysbiosis is linked to hypertension
#MMPMID25870193
Yang T
; Santisteban MM
; Rodriguez V
; Li E
; Ahmari N
; Carvajal JM
; Zadeh M
; Gong M
; Qi Y
; Zubcevic J
; Sahay B
; Pepine CJ
; Raizada MK
; Mohamadzadeh M
Hypertension
2015[Jun]; 65
(6
): 1331-40
PMID25870193
show ga
Emerging evidence suggests that gut microbiota is critical in the maintenance of
physiological homeostasis. This study was designed to test the hypothesis that
dysbiosis in gut microbiota is associated with hypertension because genetic,
environmental, and dietary factors profoundly influence both gut microbiota and
blood pressure. Bacterial DNA from fecal samples of 2 rat models of hypertension
and a small cohort of patients was used for bacterial genomic analysis. We
observed a significant decrease in microbial richness, diversity, and evenness in
the spontaneously hypertensive rat, in addition to an increased
Firmicutes/Bacteroidetes ratio. These changes were accompanied by decreases in
acetate- and butyrate-producing bacteria. In addition, the microbiota of a small
cohort of human hypertensive patients was found to follow a similar dysbiotic
pattern, as it was less rich and diverse than that of control subjects. Similar
changes in gut microbiota were observed in the chronic angiotensin II infusion
rat model, most notably decreased microbial richness and an increased
Firmicutes/Bacteroidetes ratio. In this model, we evaluated the efficacy of oral
minocycline in restoring gut microbiota. In addition to attenuating high blood
pressure, minocycline was able to rebalance the dysbiotic hypertension gut
microbiota by reducing the Firmicutes/Bacteroidetes ratio. These observations
demonstrate that high blood pressure is associated with gut microbiota dysbiosis,
both in animal and human hypertension. They suggest that dietary intervention to
correct gut microbiota could be an innovative nutritional therapeutic strategy
for hypertension.
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