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2016 ; 31
(5
): 327-35
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Gut Microbiota: Modulation of Host Physiology in Obesity
#MMPMID27511459
Nehra V
; Allen JM
; Mailing LJ
; Kashyap PC
; Woods JA
Physiology (Bethesda)
2016[Sep]; 31
(5
): 327-35
PMID27511459
show ga
Many factors are involved in weight gain and metabolic disturbances associated
with obesity. The gut microbiota has been of particular interest in recent years,
since both human and animal studies have increased our understanding of the
delicate symbiosis between the trillions of microbes that reside in the GI tract
and the host. It has been suggested that disruption of this mutual tolerance may
play a significant role in modulating host physiology during obesity.
Environmental influences such as diet, exercise, and early life exposures can
significantly impact the composition of the microbiota, and this dysbiosis can in
turn lead to increased host adiposity via a number of different mechanisms. The
ability of the microbiota to regulate host fat deposition, metabolism, and immune
function makes it an attractive target for achieving sustained weight loss.
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