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2015 ; 39
(3
): 198-203
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Gut Microbiota and Metabolic Disorders
#MMPMID26124989
Hur KY
; Lee MS
Diabetes Metab J
2015[Jun]; 39
(3
): 198-203
PMID26124989
show ga
Gut microbiota plays critical physiological roles in the energy extraction and in
the control of local or systemic immunity. Gut microbiota and its disturbance
also appear to be involved in the pathogenesis of diverse diseases including
metabolic disorders, gastrointestinal diseases, cancer, etc. In the metabolic
point of view, gut microbiota can modulate lipid accumulation, lipopolysaccharide
content and the production of short-chain fatty acids that affect food intake,
inflammatory tone, or insulin signaling. Several strategies have been developed
to change gut microbiota such as prebiotics, probiotics, certain antidiabetic
drugs or fecal microbiota transplantation, which have diverse effects on body
metabolism and on the development of metabolic disorders.