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2015 ; 10
(12
): e0145274
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Gut Dysbiosis in Patients with Anorexia Nervosa
#MMPMID26682545
Morita C
; Tsuji H
; Hata T
; Gondo M
; Takakura S
; Kawai K
; Yoshihara K
; Ogata K
; Nomoto K
; Miyazaki K
; Sudo N
PLoS One
2015[]; 10
(12
): e0145274
PMID26682545
show ga
Anorexia nervosa (AN) is a psychological illness with devastating physical
consequences; however, its pathophysiological mechanism remains unclear. Because
numerous reports have indicated the importance of gut microbiota in the
regulation of weight gain, it is reasonable to speculate that AN patients might
have a microbial imbalance, i.e. dysbiosis, in their gut. In this study, we
compared the fecal microbiota of female patients with AN (n = 25), including
restrictive (ANR, n = 14) and binge-eating (ANBP, n = 11) subtypes, with those of
age-matched healthy female controls (n = 21) using the Yakult Intestinal
Flora-SCAN based on 16S or 23S rRNA-targeted RT-quantitative PCR technology. AN
patients had significantly lower amounts of total bacteria and obligate anaerobes
including those from the Clostridium coccoides group, Clostridium leptum
subgroup, and Bacteroides fragilis group than the age-matched healthy women.
Lower numbers of Streptococcus were also found in the AN group than in the
control group. In the analysis based on AN subtypes, the counts of the
Bacteroides fragilis group in the ANR and ANBP groups and the counts of the
Clostridium coccoides group in the ANR group were significantly lower than those
in the control group. The detection rate of the Lactobacillus plantarum subgroup
was significantly lower in the AN group than in the control group. The AN group
had significantly lower acetic and propionic acid concentrations in the feces
than the control group. Moreover, the subtype analysis showed that the fecal
concentrations of acetic acid were lower in the ANR group than in the control
group. Principal component analysis confirmed a clear difference in the bacterial
components between the AN patients and healthy women. Collectively, these results
clearly indicate the existence of dysbiosis in the gut of AN patients.
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