Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20015202
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cell+Mol+Med
2011 ; 15
(8
): 1645-87
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Growth factors in ischemic stroke
#MMPMID20015202
Lanfranconi S
; Locatelli F
; Corti S
; Candelise L
; Comi GP
; Baron PL
; Strazzer S
; Bresolin N
; Bersano A
J Cell Mol Med
2011[Aug]; 15
(8
): 1645-87
PMID20015202
show ga
Data from pre-clinical and clinical studies provide evidence that
colony-stimulating factors (CSFs) and other growth factors (GFs) can improve
stroke outcome by reducing stroke damage through their anti-apoptotic and
anti-inflammatory effects, and by promoting angiogenesis and neurogenesis. This
review provides a critical and up-to-date literature review on CSF use in stroke.
We searched for experimental and clinical studies on haemopoietic GFs such as
granulocyte CSF, erythropoietin, granulocyte-macrophage colony-stimulating
factor, stem cell factor (SCF), vascular endothelial GF, stromal cell-derived
factor-1? and SCF in ischemic stroke. We also considered studies on insulin-like
growth factor-1 and neurotrophins. Despite promising results from animal models,
the lack of data in human beings hampers efficacy assessments of GFs on stroke
outcome. We provide a comprehensive and critical view of the present knowledge
about GFs and stroke, and an overview of ongoing and future prospects.
free
free
free
