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10.3390/v8100296 http://scihub22266oqcxt.onion/10.3390/v8100296 C5086628!5086628 !27783038     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27783038 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Viruses 2016 ; 8 (10 ): ä Nephropedia Template TP {{tp|p=27783038 |t=2016. Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential |pdf=|usr=}}{{27783038 }} gab.com Text Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=27783038 #FOAvip Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors discovered to date. It is currently being developed as a microbicide with broad-spectrum activity against several enveloped viruses. GRFT can inhibit human immunodeficiency virus (HIV) infection at picomolar concentrations, surpassing the ability of most anti-HIV agents. The potential to inhibit other viruses as well as parasites has also been demonstrated. Griffithsin's antiviral activity stems from its ability to bind terminal mannoses present in high-mannose oligosaccharides and crosslink these glycans on the surface of the viral envelope glycoproteins. Here, we review structural and biochemical studies that established mode of action and facilitated construction of GRFT analogs, mechanisms that may lead to resistance, and in vitro and pre-clinical results that support the therapeutic potential of this lectin. Twit Text FOAVip Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=27783038 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27783038 #FOAvip English Wikipedia <ref>{{Cite pmid|27783038 }}</ref> Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential #MMPMID27783038 Lusvarghi S ; Bewley CA Viruses 2016[Oct]; 8 (10 ): ä PMID27783038 show ga Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors discovered to date. It is currently being developed as a microbicide with broad-spectrum activity against several enveloped viruses. GRFT can inhibit human immunodeficiency virus (HIV) infection at picomolar concentrations, surpassing the ability of most anti-HIV agents. The potential to inhibit other viruses as well as parasites has also been demonstrated. Griffithsin's antiviral activity stems from its ability to bind terminal mannoses present in high-mannose oligosaccharides and crosslink these glycans on the surface of the viral envelope glycoproteins. Here, we review structural and biochemical studies that established mode of action and facilitated construction of GRFT analogs, mechanisms that may lead to resistance, and in vitro and pre-clinical results that support the therapeutic potential of this lectin. |Animals [MESH] |Antiparasitic Agents/pharmacology [MESH] |Antiviral Agents/*pharmacology [MESH] |Drug Evaluation, Preclinical [MESH] |Humans [MESH] |Microbial Sensitivity Tests [MESH] |Plant Lectins/*pharmacology [MESH]Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potentia(epmc).pdf DeepDyve Pubget Overpricing