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10.1097/MD.0000000000003208 http://scihub22266oqcxt.onion/10.1097/MD.0000000000003208 C4998546!4998546 !27043685     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27043685 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Medicine+(Baltimore) 2016 ; 95 (13 ): e3208 Nephropedia Template TP {{tp|p=27043685 |t=2016. Gray Matter Involvement in Radiologically Isolated Syndrome |pdf=|usr=}}{{27043685 }} gab.com Text Gray Matter Involvement in Radiologically Isolated Syndrome JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=27043685 #FOAvip The unanticipated magnetic resonance imaging (MRI) detection in the brain of asymptomatic subjects of white matter lesions suggestive of multiple sclerosis has recently been named as radiologically isolated syndrome (RIS). The pathophysiological processes of RIS remain largely unknown and questions as to whether gray matter alterations actually occur in this entity are yet to be investigated in more detail. By means of a 3 T multimodal MRI approach, we searched for cortical and deep gray matter changes in a cohort of RIS patients. Seventeen RIS patients, 17 clinically isolated syndrome (CIS) patients (median disease duration from symptom onset?=?12 months), and 17 healthy controls underwent MRI and neuropsychological testing. Normalized deep gray matter volumes and regional cortical thickness were assessed using FreeSurfer. SIENAX was used to obtain normalized global and cortical brain volumes. Voxelwise morphometry analysis was performed by using SPM8 software to localize regions of brain tissue showing significant changes of fractional anisotropy or mean diffusivity. Although no differences were observed between CIS and healthy controls groups, RIS patients showed significantly lower normalized cortical volume (673?±?27.07 vs 641?±?35.88 [cm³?×?10³, Tukey P test?=?0.009) and mean thalamic volume (0.0051?±?0.4 vs 0.0046?±?0.4?mm, P?=?0.014) compared with healthy controls. RIS patients also showed significant thinning in a number of cortical areas, that were primarily distributed in frontal and temporal lobes (P?<?0.05, uncorrected). Strong correlations were observed between T2-white matter lesion volume and regional cortical thickness (rho spearman ranging from 0.60 to 0.80). Our data suggest that white matter lesions on T2-weighted images are not the only hallmark of RIS. Future longitudinal studies with larger samples are warranted to better clarify the effect of RIS-related white matter lesions on gray matter tissue. Twit Text FOAVip Gray Matter Involvement in Radiologically Isolated Syndrome ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=27043685 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27043685 #FOAvip English Wikipedia <ref>{{Cite pmid|27043685 }}</ref> Gray Matter Involvement in Radiologically Isolated Syndrome #MMPMID27043685 Labiano-Fontcuberta A ; Mato-Abad V ; Álvarez-Linera J ; Hernández-Tamames JA ; Martínez-Ginés ML ; Aladro Y ; Ayuso L ; Domingo-Santos Á ; Benito-León J Medicine (Baltimore) 2016[Mar]; 95 (13 ): e3208 PMID27043685 show ga The unanticipated magnetic resonance imaging (MRI) detection in the brain of asymptomatic subjects of white matter lesions suggestive of multiple sclerosis has recently been named as radiologically isolated syndrome (RIS). The pathophysiological processes of RIS remain largely unknown and questions as to whether gray matter alterations actually occur in this entity are yet to be investigated in more detail. By means of a 3 T multimodal MRI approach, we searched for cortical and deep gray matter changes in a cohort of RIS patients. Seventeen RIS patients, 17 clinically isolated syndrome (CIS) patients (median disease duration from symptom onset?=?12 months), and 17 healthy controls underwent MRI and neuropsychological testing. Normalized deep gray matter volumes and regional cortical thickness were assessed using FreeSurfer. SIENAX was used to obtain normalized global and cortical brain volumes. Voxelwise morphometry analysis was performed by using SPM8 software to localize regions of brain tissue showing significant changes of fractional anisotropy or mean diffusivity. Although no differences were observed between CIS and healthy controls groups, RIS patients showed significantly lower normalized cortical volume (673?±?27.07 vs 641?±?35.88 [cm³?×?10³, Tukey P test?=?0.009) and mean thalamic volume (0.0051?±?0.4 vs 0.0046?±?0.4?mm, P?=?0.014) compared with healthy controls. RIS patients also showed significant thinning in a number of cortical areas, that were primarily distributed in frontal and temporal lobes (P? |Adult [MESH] |Brain Diseases/*pathology [MESH] |Female [MESH] |Gray Matter/*pathology [MESH] |Humans [MESH] |Magnetic Resonance Imaging/*methods [MESH] |Male [MESH] |Middle Aged [MESH] |Neuropsychological Tests [MESH] |Syndrome [MESH]Gray Matter Involvement in Radiologically Isolated Syndrome (epmc).pdf DeepDyve Pubget Overpricing