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2018 ; 11
(2
): 219-221
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Granulomatous interstitial nephritis secondary to adalimumab therapy
#MMPMID29644062
Sandys V
; Moloney B
; Lane L
; Qazi J
; Doyle B
; Barry M
; Leavey S
; Conlon P
Clin Kidney J
2018[Apr]; 11
(2
): 219-221
PMID29644062
show ga
Tumour necrosis factor ? (TNF-?) inhibitors are frequently used for the treatment
of immune-mediated diseases. Conversely, cytokine therapy has the potential to
paradoxically induce autoimmunity. A number of case reports have emerged
concerning sarcoid-like granulomatosis secondary to TNF-? therapy, an adverse
effect that typically affects the pulmonary and cutaneous systems. Granulomatous
interstitial nephritis (GIN) is a relatively unknown, relatively under-reported
consequence of adalimumab therapy that can have important clinical implications.
To our knowledge, this is the first case report of GIN secondary to anti-TNF-?
therapy necessitating a prolonged period of dialysis and the first report
demonstrating the successful use of secukinumab as an alternative
immunomodulatory agent.