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10.1007/s00412-015-0527-8 http://scihub22266oqcxt.onion/10.1007/s00412-015-0527-8 C4714962!4714962!26174338     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26174338&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26174338.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Chromosoma 2016 ; 125 (3): 361-71 Nephropedia Template TP {{tp|p=26174338|t=2016. Grabbing the Genome by the NADs |pdf=|usr=}}{{26174338}} gab.com Text Grabbing the Genome by the NADs JO: Chromosoma http://www.kidney.de/pget.php?&tw=1&pmid=26174338 #FOAvip The regions of the genome that interact frequently with the nucleolus have been termed Nucleolar Associated Domains (NADs). Deep-sequencing and DNA-FISH experiments have revealed that these domains are enriched for repetitive elements, regions of the inactive X chromosome (Xi), and several RNA polymerase III-transcribed genes. NADs are often marked by chromatin modifications characteristic of heterochromatin, including H3K27me3, H3K9me3, and H4K20me3, and artificial targeting of genes to this area is correlated with reduced expression. It has therefore been hypothesized that NAD localization to the nucleolar periphery contributes to the establishment and/or maintenance of heterochromatic silencing. Recently published studies from several multicellular eukaryotes have begun to reveal the trans-acting factors involved in NAD localization, including the insulator protein CTCF, chromatin assembly factor CAF-1 subunit p150, several nucleolar proteins, and two long non-coding RNAs (lncRNAs). The mechanisms by which these factors coordinate with one another in regulating NAD localization and/or silencing are still unknown. This review will summarize recently published studies, discuss where additional research is required, and speculate about the mechanistic and functional implications of genome organization around the nucleolus. Twit Text FOAVip Grabbing the Genome by the NADs ????Chromosoma http://www.kidney.de/pget.php?&tw=1&pmid=26174338 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26174338 #FOAvip English Wikipedia <ref>{{Cite pmid|26174338}}</ref> Grabbing the Genome by the NADs #MMPMID26174338 Matheson TD; Kaufman PD Chromosoma 2016[Jun]; 125 (3): 361-71 PMID26174338show ga The regions of the genome that interact frequently with the nucleolus have been termed Nucleolar Associated Domains (NADs). Deep-sequencing and DNA-FISH experiments have revealed that these domains are enriched for repetitive elements, regions of the inactive X chromosome (Xi), and several RNA polymerase III-transcribed genes. NADs are often marked by chromatin modifications characteristic of heterochromatin, including H3K27me3, H3K9me3, and H4K20me3, and artificial targeting of genes to this area is correlated with reduced expression. It has therefore been hypothesized that NAD localization to the nucleolar periphery contributes to the establishment and/or maintenance of heterochromatic silencing. Recently published studies from several multicellular eukaryotes have begun to reveal the trans-acting factors involved in NAD localization, including the insulator protein CTCF, chromatin assembly factor CAF-1 subunit p150, several nucleolar proteins, and two long non-coding RNAs (lncRNAs). The mechanisms by which these factors coordinate with one another in regulating NAD localization and/or silencing are still unknown. This review will summarize recently published studies, discuss where additional research is required, and speculate about the mechanistic and functional implications of genome organization around the nucleolus. äGrabbing the Genome by the NADs (epmc).pdf DeepDyve Pubget Overpricing