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10.3389/fnins.2015.00340 http://scihub22266oqcxt.onion/10.3389/fnins.2015.00340 C4585163!4585163!26441511     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26441511.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Neurosci 2015 ; 9 (ä): ä Nephropedia Template TP {{tp|p=26441511|t=2015. Golgi fragmentation in Alzheimer s disease |pdf=|usr=}}{{26441511}} gab.com Text Golgi fragmentation in Alzheimer s disease JO: Front Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26441511 #FOAvip The Golgi apparatus is an essential cellular organelle for post-translational modifications, sorting, and trafficking of membrane and secretory proteins. Proper functionality of the Golgi requires the formation of its unique cisternal-stacking morphology. The Golgi structure is disrupted in a variety of neurodegenerative diseases, suggesting a common mechanism and contribution of Golgi defects in neurodegenerative disorders. A recent study on Alzheimer's disease (AD) revealed that phosphorylation of the Golgi stacking protein GRASP65 disrupts its function in Golgi structure formation, resulting in Golgi fragmentation. Inhibiting GRASP65 phosphorylation restores the Golgi morphology from A?-induced fragmentation and reduces A? production. Perturbing Golgi structure and function in neurons may directly impact trafficking, processing, and sorting of a variety of proteins essential for synaptic and dendritic integrity. Therefore, Golgi defects may ultimately promote the development of AD. In the current review, we focus on the cellular impact of impaired Golgi morphology and its potential relationship to AD disease development. Twit Text FOAVip Golgi fragmentation in Alzheimer s disease ????Front Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26441511 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26441511 #FOAvip English Wikipedia <ref>{{Cite pmid|26441511}}</ref> Golgi fragmentation in Alzheimer s disease #MMPMID26441511 Joshi G; Bekier ME; Wang Y Front Neurosci 2015[]; 9 (ä): ä PMID26441511show ga The Golgi apparatus is an essential cellular organelle for post-translational modifications, sorting, and trafficking of membrane and secretory proteins. Proper functionality of the Golgi requires the formation of its unique cisternal-stacking morphology. The Golgi structure is disrupted in a variety of neurodegenerative diseases, suggesting a common mechanism and contribution of Golgi defects in neurodegenerative disorders. A recent study on Alzheimer's disease (AD) revealed that phosphorylation of the Golgi stacking protein GRASP65 disrupts its function in Golgi structure formation, resulting in Golgi fragmentation. Inhibiting GRASP65 phosphorylation restores the Golgi morphology from A?-induced fragmentation and reduces A? production. Perturbing Golgi structure and function in neurons may directly impact trafficking, processing, and sorting of a variety of proteins essential for synaptic and dendritic integrity. Therefore, Golgi defects may ultimately promote the development of AD. In the current review, we focus on the cellular impact of impaired Golgi morphology and its potential relationship to AD disease development. äGolgi fragmentation in Alzheimer s disease (epmc).pdf DeepDyve Pubget Overpricing