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2016 ; 17
(10
): ä Nephropedia Template TP
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Glycosphingolipid-Protein Interaction in Signal Transduction
#MMPMID27754465
Russo D
; Parashuraman S
; D'Angelo G
Int J Mol Sci
2016[Oct]; 17
(10
): ä PMID27754465
show ga
Glycosphingolipids (GSLs) are a class of ceramide-based glycolipids essential for
embryo development in mammals. The synthesis of specific GSLs depends on the
expression of distinctive sets of GSL synthesizing enzymes that is tightly
regulated during development. Several reports have described how cell surface
receptors can be kept in a resting state or activate alternative signalling
events as a consequence of their interaction with GSLs. Specific GSLs, indeed,
interface with specific protein domains that are found in signalling molecules
and which act as GSL sensors to modify signalling responses. The regulation
exerted by GSLs on signal transduction is orthogonal to the ligand-receptor axis,
as it usually does not directly interfere with the ligand binding to receptors.
Due to their properties of adjustable production and orthogonal action on
receptors, GSLs add a new dimension to the control of the signalling in
development. GSLs can, indeed, dynamically influence progenitor cell response to
morphogenetic stimuli, resulting in alternative differentiation fates. Here, we
review the available literature on GSL-protein interactions and their effects on
cell signalling and development.
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