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10.1128/AAC.01998-16 http://scihub22266oqcxt.onion/10.1128/AAC.01998-16 C5278739!5278739 !27872074     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27872074 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Antimicrob+Agents+Chemother 2017 ; 61 (2 ): ä Nephropedia Template TP {{tp|p=27872074 |t=2017. Glycoside Hydrolases Degrade Polymicrobial Bacterial Biofilms in Wounds |pdf=|usr=}}{{27872074 }} gab.com Text Glycoside Hydrolases Degrade Polymicrobial Bacterial Biofilms in Wounds JO: Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=27872074 #FOAvip The persistent nature of chronic wounds leaves them highly susceptible to invasion by a variety of pathogens that have the ability to construct an extracellular polymeric substance (EPS). This EPS makes the bacterial population, or biofilm, up to 1,000-fold more antibiotic tolerant than planktonic cells and makes wound healing extremely difficult. Thus, compounds which have the ability to degrade biofilms, but not host tissue components, are highly sought after for clinical applications. In this study, we examined the efficacy of two glycoside hydrolases, ?-amylase and cellulase, which break down complex polysaccharides, to effectively disrupt Staphylococcus aureus and Pseudomonas aeruginosa monoculture and coculture biofilms. We hypothesized that glycoside hydrolase therapy would significantly reduce EPS biomass and convert bacteria to their planktonic state, leaving them more susceptible to conventional antimicrobials. Treatment of S. aureus and P. aeruginosa biofilms, grown in vitro and in vivo, with solutions of ?-amylase and cellulase resulted in significant reductions in biomass, dissolution of the biofilm, and an increase in the effectiveness of subsequent antibiotic treatments. These data suggest that glycoside hydrolase therapy represents a potential safe, effective, and new avenue of treatment for biofilm-related infections. Twit Text FOAVip Glycoside Hydrolases Degrade Polymicrobial Bacterial Biofilms in Wounds ????Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=27872074 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27872074 #FOAvip English Wikipedia <ref>{{Cite pmid|27872074 }}</ref> Glycoside Hydrolases Degrade Polymicrobial Bacterial Biofilms in Wounds #MMPMID27872074 Fleming D ; Chahin L ; Rumbaugh K Antimicrob Agents Chemother 2017[Feb]; 61 (2 ): ä PMID27872074 show ga The persistent nature of chronic wounds leaves them highly susceptible to invasion by a variety of pathogens that have the ability to construct an extracellular polymeric substance (EPS). This EPS makes the bacterial population, or biofilm, up to 1,000-fold more antibiotic tolerant than planktonic cells and makes wound healing extremely difficult. Thus, compounds which have the ability to degrade biofilms, but not host tissue components, are highly sought after for clinical applications. In this study, we examined the efficacy of two glycoside hydrolases, ?-amylase and cellulase, which break down complex polysaccharides, to effectively disrupt Staphylococcus aureus and Pseudomonas aeruginosa monoculture and coculture biofilms. We hypothesized that glycoside hydrolase therapy would significantly reduce EPS biomass and convert bacteria to their planktonic state, leaving them more susceptible to conventional antimicrobials. Treatment of S. aureus and P. aeruginosa biofilms, grown in vitro and in vivo, with solutions of ?-amylase and cellulase resulted in significant reductions in biomass, dissolution of the biofilm, and an increase in the effectiveness of subsequent antibiotic treatments. These data suggest that glycoside hydrolase therapy represents a potential safe, effective, and new avenue of treatment for biofilm-related infections. |Anti-Bacterial Agents/pharmacology [MESH] |Biofilms/*drug effects [MESH] |Cellulase/metabolism [MESH] |Glycoside Hydrolases/*metabolism [MESH] |Pseudomonas aeruginosa/drug effects [MESH] |Staphylococcus aureus/drug effects [MESH]Glycoside Hydrolases Degrade Polymicrobial Bacterial Biofilms in Wound(epmc).pdf DeepDyve Pubget Overpricing