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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nat+Commun
2016 ; 7
(ä): 12240
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Glycolytic regulation of cell rearrangement in angiogenesis
#MMPMID27436424
Cruys B
; Wong BW
; Kuchnio A
; Verdegem D
; Cantelmo AR
; Conradi LC
; Vandekeere S
; Bouché A
; Cornelissen I
; Vinckier S
; Merks RM
; Dejana E
; Gerhardt H
; Dewerchin M
; Bentley K
; Carmeliet P
Nat Commun
2016[Jul]; 7
(ä): 12240
PMID27436424
show ga
During vessel sprouting, endothelial cells (ECs) dynamically rearrange positions
in the sprout to compete for the tip position. We recently identified a key role
for the glycolytic activator PFKFB3 in vessel sprouting by regulating
cytoskeleton remodelling, migration and tip cell competitiveness. It is, however,
unknown how glycolysis regulates EC rearrangement during vessel sprouting. Here
we report that computational simulations, validated by experimentation, predict
that glycolytic production of ATP drives EC rearrangement by promoting filopodia
formation and reducing intercellular adhesion. Notably, the simulations correctly
predicted that blocking PFKFB3 normalizes the disturbed EC rearrangement in high
VEGF conditions, as occurs during pathological angiogenesis. This
interdisciplinary study integrates EC metabolism in vessel sprouting, yielding
mechanistic insight in the control of vessel sprouting by glycolysis, and
suggesting anti-glycolytic therapy for vessel normalization in cancer and
non-malignant diseases.
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