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2014 ; 24
(12
): 1275-82
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Glycobiology of ocular angiogenesis
#MMPMID25108228
Markowska AI
; Cao Z
; Panjwani N
Glycobiology
2014[Dec]; 24
(12
): 1275-82
PMID25108228
show ga
Ocular neovascularization can affect almost all the tissues of the eye: the
cornea, the iris, the retina, and the choroid. Pathological neovascularization is
the underlying cause of vision loss in common ocular conditions such as diabetic
retinopathy, retinopathy of prematurity and age-related macular
neovascularization. Glycosylation is the most common covalent posttranslational
modification of proteins in mammalian cells. A growing body of evidence
demonstrates that glycosylation influences the process of angiogenesis and
impacts activation, proliferation, and migration of endothelial cells as well as
the interaction of angiogenic endothelial cells with other cell types necessary
to form blood vessels. Recent studies have provided evidence that members of the
galectin class of ?-galactoside-binding proteins modulate angiogenesis by novel
carbohydrate-based recognition systems involving interactions between glycans of
angiogenic cell surface receptors and galectins. This review discusses the
significance of glycosylation and the role of galectins in the pathogenesis of
ocular neovascularization.
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