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2015 ; 16
(3
): 174-8
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Glyceryl trinitrate for the treatment of preterm labor
#MMPMID26401112
Çal??kan ?
; Narin MA
; Dede FS
; Narin R
; Dede H
; Kandemir Ö
J Turk Ger Gynecol Assoc
2015[]; 16
(3
): 174-8
PMID26401112
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OBJECTIVE: This study was conducted to compare the tocolytic efficacy of
glyceryltrinitrate (GTN) with that of magnesium sulfate (MgSO4) and to
investigate serum nitric oxide metabolites before and after tocolysis. MATERIAL
AND METHODS: In total, 48 women between 27 and 34 weeks' gestation with
threatened preterm labor and intact membranes were randomly allocated to receive
either GTN or MgSO4 tocolysis. Main outcome measures included tocolytic efficacy
and maternal side effect(s) of the tocolytic agent. Obstetric and neonatal
outcomes as well as pretreatment and posttreatment nitric oxide (NO) metabolites
were assessed. RESULTS: Forty-one patients were included into the final analysis.
Uterine contraction cessation times were 3.66±1.28 and 6.83±3.47 hours for GTN
and MgSO4 groups, respectively. Similarly, maternal side effects were
significantly lower in the GTN group than in the MgSO4 group, and no serious
maternal side effects were recorded. Serum NO metabolite levels before treatment
were significantly lower in the treatment groups than in the controls. Serum
nitrite levels were significantly increased after tocolytic treatment both in
MgSO4 and GTN groups. CONCLUSION: GTN effectively delays preterm delivery and
reduces neonatal morbidity and mortality with less maternal side effects and
seems to be an effective and safe alternative to MgSO4.
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