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Glutathione peroxidases as oncotargets
#MMPMID29108391
Jiao Y
; Wang Y
; Guo S
; Wang G
Oncotarget
2017[Oct]; 8
(45
): 80093-80102
PMID29108391
show ga
Oxidative stress is a disturbance in the equilibrium among free radicals,
reactive oxygen species, and endogenous antioxidant defense mechanisms. Oxidative
stress is a result of imbalance between the production of reactive oxygen and the
biological system's ability to detoxify the reactive intermediates or to repair
the resulting damage. Mounting evidence has implicated oxidative stress in
various physiological and pathological processes, including DNA damage,
proliferation, cell adhesion, and survival of cancer cells. Glutathione
peroxidases (GPxs) (EC 1.11.1.9) are an enzyme family with peroxidase activity
whose main biological roles are to protect organisms from oxidative damage by
reducing lipid hydroperoxides as well as free hydrogen peroxide. Currently, 8
sub-members of GPxs have been identified in humans, all capable of reducing
H(2)O(2) and soluble fatty acid hydroperoxides. A large number of publications
has demonstrated that GPxs have significant roles in different stages of
carcinogenesis. In this review, we will update recent progress in the study of
the roles of GPxs in cancer. Better mechanistic understanding of GPxs will
potentially contribute to the development and advancement of improved cancer
treatment models.
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