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Wiggins RC
; Alpers CE
; Holzman LB
; He JC
; Salant DJ
; Chugh SS
; Natarajan R
; Trachtman H
; Brasile L
; Star RA
; Rys-Sikora KE
; Moxey-Mims MM
; Flessner MF
Clin J Am Soc Nephrol
2014[Jun]; 9
(6
): 1138-40
PMID24700796
show ga
The National Institute of Diabetes and Digestive and Kidney Diseases-supported
Kidney Research National Dialogue asked the scientific community to formulate and
prioritize research objectives aimed at improved understanding of kidney function
and disease progression. Over the past 2 years, 1600 participants posted almost
300 ideas covering all areas of kidney disease. An overriding theme that evolved
through these discussions is the need to move beyond pathology to take advantage
of basic science and clinical research opportunities to improve diagnostic
classification and therapeutic options for people with primary glomerular
disease. High-priority research areas included focus on therapeutic targets in
glomerular endothelium and podocytes, regenerating podocytes through
developmental pathways, use of longitudinal phenotypically defined disease
cohorts to improve classification schemes, identifying biomarkers,
disease-specific therapeutics, autoantibody triggers, and changing the clinical
research culture to promote participation in clinical trials. Together, these
objectives provide a path forward for improving clinical outcomes of glomerular
disease.
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