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2017 ; 54
(3
): 484-489
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Glomerular Lesions in Proteinuric Miniature Schnauzer Dogs
#MMPMID28005494
Furrow E
; Lees GE
; Brown CA
; Cianciolo RE
Vet Pathol
2017[May]; 54
(3
): 484-489
PMID28005494
show ga
Miniature Schnauzer dogs are predisposed to idiopathic hypertriglyerceridemia,
which increases risk for diseases such as pancreatitis and gallbladder mucocele.
Recently, elevated triglyceride concentrations have been associated with
proteinuria in this breed, although it is difficult to determine which
abnormality is primary. Retrospective review of renal tissue from 27 proteinuric
Miniature Schnauzers revealed that 20 dogs had ultrastructural evidence of
osmophilic globules consistent with lipid in glomerular tufts. Seven of these
dogs had lipid thromboemboli in glomerular capillary loops that distorted their
shape and compressed circulating erythrocytes. Triglyceride concentrations were
reported in 6 of these 7 dogs, and all were hypertriglyceridemic. In addition,
glomerular lipidosis (defined as accumulation of foam cells within peripheral
capillary loops) was identified in a single dog. The remaining 12 dogs had
smaller amounts of lipid that could only be identified ultrastructurally. Neither
signalment data nor clinicopathologic parameters (serum albumin, serum
creatinine, urine protein-to-creatinine ratio, and blood pressure) differed among
the various types of lipid lesions. During the time course of this study, all
dogs diagnosed with glomerular lipid thromboemboli were Miniature Schnauzers,
underscoring the importance of recognizing these clear spaces within capillary
loops as lipid.