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2015 ; 4
(6
): 437-60
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English Wikipedia
Ghrelin
#MMPMID26042199
Müller TD
; Nogueiras R
; Andermann ML
; Andrews ZB
; Anker SD
; Argente J
; Batterham RL
; Benoit SC
; Bowers CY
; Broglio F
; Casanueva FF
; D'Alessio D
; Depoortere I
; Geliebter A
; Ghigo E
; Cole PA
; Cowley M
; Cummings DE
; Dagher A
; Diano S
; Dickson SL
; Diéguez C
; Granata R
; Grill HJ
; Grove K
; Habegger KM
; Heppner K
; Heiman ML
; Holsen L
; Holst B
; Inui A
; Jansson JO
; Kirchner H
; Korbonits M
; Laferrère B
; LeRoux CW
; Lopez M
; Morin S
; Nakazato M
; Nass R
; Perez-Tilve D
; Pfluger PT
; Schwartz TW
; Seeley RJ
; Sleeman M
; Sun Y
; Sussel L
; Tong J
; Thorner MO
; van der Lely AJ
; van der Ploeg LH
; Zigman JM
; Kojima M
; Kangawa K
; Smith RG
; Horvath T
; Tschöp MH
Mol Metab
2015[Jun]; 4
(6
): 437-60
PMID26042199
show ga
BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999
as the endogenous ligand of the growth hormone secretagogue receptor. Increasing
evidence supports more complicated and nuanced roles for the hormone, which go
beyond the regulation of systemic energy metabolism. SCOPE OF REVIEW: In this
review, we discuss the diverse biological functions of ghrelin, the regulation of
its secretion, and address questions that still remain 15 years after its
discovery. MAJOR CONCLUSIONS: In recent years, ghrelin has been found to have a
plethora of central and peripheral actions in distinct areas including learning
and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward
seeking behavior, taste sensation and glucose metabolism.