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2015 ; 11
(2
): 90-95
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Ghrelin - Physiological Functions and Regulation
#MMPMID29632576
Ibrahim Abdalla MM
Eur Endocrinol
2015[Aug]; 11
(2
): 90-95
PMID29632576
show ga
Ghrelin is an orexigenic peptide predominantly secreted from the stomach and
stimulates appetite and growth hormone (GH) release. Studies have provided
evidence that ghrelin exercises a wide range of functions, including regulation
of food intake and energy metabolism, modulation of cardiovascular function,
stimulation of osteoblast proliferation and bone formation and stimulation of
neurogenesis and myogenesis. In the gastrointestinal system, ghrelin affects
multiple functions, including secretion of gastric acid, gastric motility and
pancreatic protein output. Most of these functions have been attributed to the
actions of acylated ghrelin. The balance among its secretion rate, degradation
rate and clearance rate determines the circulating level of ghrelin. This review
explains what ghrelin is, its physiological functions and the factors that
influence its level.