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10.1155/2017/9361802 http://scihub22266oqcxt.onion/10.1155/2017/9361802 C5424489!5424489 !28529959     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28529959 &cmd=llinks): Failed to open stream: HTTP request failed! 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Getting "Inside" Type I IFNs: Type I IFNs in Intracellular Bacterial Infections |pdf=|usr=}}{{28529959 }} gab.com Text Getting "Inside" Type I IFNs: Type I IFNs in Intracellular Bacterial Infections JO: J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=28529959 #FOAvip Type I interferons represent a unique and complex group of cytokines, serving many purposes during innate and adaptive immunity. Discovered in the context of viral infections, type I IFNs are now known to have myriad effects in infectious and autoimmune disease settings. Type I IFN signaling during bacterial infections is dependent on many factors including whether the infecting bacterium is intracellular or extracellular, as different signaling pathways are activated. As such, the repercussions of type I IFN induction can positively or negatively impact the disease outcome. This review focuses on type I IFN induction and downstream consequences during infection with the following intracellular bacteria: Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Salmonella enterica serovar Typhimurium, Francisella tularensis, Brucella abortus, Legionella pneumophila, and Coxiella burnetii. Intracellular bacterial infections are unique because the bacteria must avoid, circumvent, and even co-opt microbial "sensing" mechanisms in order to reside and replicate within a host cell. Furthermore, life inside a host cell makes intracellular bacteria more difficult to target with antibiotics. Because type I IFNs are important immune effectors, modulating this pathway may improve disease outcomes. But first, it is critical to understand the context-dependent effects of the type I IFN pathway in intracellular bacterial infections. Twit Text FOAVip Getting "Inside" Type I IFNs: Type I IFNs in Intracellular Bacterial Infections ????J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=28529959 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28529959 #FOAvip English Wikipedia <ref>{{Cite pmid|28529959 }}</ref> Getting "Inside" Type I IFNs: Type I IFNs in Intracellular Bacterial Infections #MMPMID28529959 Snyder DT ; Hedges JF ; Jutila MA J Immunol Res 2017[]; 2017 (ä): 9361802 PMID28529959 show ga Type I interferons represent a unique and complex group of cytokines, serving many purposes during innate and adaptive immunity. Discovered in the context of viral infections, type I IFNs are now known to have myriad effects in infectious and autoimmune disease settings. Type I IFN signaling during bacterial infections is dependent on many factors including whether the infecting bacterium is intracellular or extracellular, as different signaling pathways are activated. As such, the repercussions of type I IFN induction can positively or negatively impact the disease outcome. This review focuses on type I IFN induction and downstream consequences during infection with the following intracellular bacteria: Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Salmonella enterica serovar Typhimurium, Francisella tularensis, Brucella abortus, Legionella pneumophila, and Coxiella burnetii. Intracellular bacterial infections are unique because the bacteria must avoid, circumvent, and even co-opt microbial "sensing" mechanisms in order to reside and replicate within a host cell. Furthermore, life inside a host cell makes intracellular bacteria more difficult to target with antibiotics. Because type I IFNs are important immune effectors, modulating this pathway may improve disease outcomes. But first, it is critical to understand the context-dependent effects of the type I IFN pathway in intracellular bacterial infections. |Animals [MESH] |Bacterial Infections/*immunology [MESH] |Cytoplasm/immunology/*microbiology [MESH] |Humans [MESH] |Interferon Type I/*immunology [MESH] |Listeria monocytogenes/immunology/physiology [MESH] |Listeriosis/immunology [MESH] |Macrophages/immunology/microbiology [MESH] |Mice [MESH] |Salmonella typhimurium/immunology/physiology [MESH]Getting "Inside" Type I IFNs: Type I IFNs in Intracellular Bacterial I(epmc).pdf DeepDyve Pubget Overpricing