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Pulm Circ
2015[Dec]; 5
(4
): 730-3
PMID26697182
show ga
Pulmonary arterial hypertension (PAH) is a progressive disease marked by the
irreversible pulmonary vascular changes of vasoconstriction, thrombosis, and
proliferation of smooth muscle and endothelial cells. The untreated clinical
course is characterized by progressive dyspnea and a median survival of less than
3 years. Many of these patients are of child-bearing age; however, pregnancy
leads to physiologic changes that are particularly poorly tolerated in PAH,
conferring a 30%-56% mortality. We present a case of PAH that spontaneously
resolved after termination of pregnancy and recurred during each of two
subsequent pregnancies. To our knowledge, this case is unique, because no cases
of spontaneous resolution of idiopathic PAH have been reported in adults, nor
have there been any reports of pulmonary hypertension that is isolated to the
gestational period.
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