Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26556906
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Geburtshilfe+Frauenheilkd
2015 ; 75
(10
): 1043-1050
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Gestational Trophoblastic Disorders: An Update in 2015
#MMPMID26556906
Stevens FT
; Katzorke N
; Tempfer C
; Kreimer U
; Bizjak GI
; Fleisch MC
; Fehm TN
Geburtshilfe Frauenheilkd
2015[Oct]; 75
(10
): 1043-1050
PMID26556906
show ga
Gestational trophoblastic diseases (GTD) are a group of pregnancy-related
disorders representing rare human tumours. They encompass premalignant disorders
including complete (CHM), partial hydatidiform mole (PHM), exaggerated placental
site (EPS), and placental-site nodule (PSN) as well as malignant disorders (also
known as "gestational trophoblastic neoplasia [GTN]") including invasive mole,
choriocarcinoma (CC), placenta-site trophoblastic tumour (PSTT), and epitheloid
trophoblastic tumours (ETT) (Fig.?1). Originally, GTD develop from abnormal
proliferation of trophoblastic tissue and form botryoid arranged vesicles.
Premalignant moles are usually treated by suction curettage while persistent and
recurrent moles and malignant forms require systemic therapy with methotrexate or
combination chemotherapy consisting of etoposide, actimomycin D, methotrexate,
vincristine, and cyclophosphamide (EMA-CO). ?-human chorion gonadotropin (?-hCG)
plays a crucial role in diagnosis and monitoring therapeutic effects. Since the
definitive diagnosis cannot be obtained by histology in most cases, persistent or
recurrent disease is diagnosed by elevated or persistent serum levels of ?-hCG.
While curing rates are described to be as high as 98?%, GTD may initially
present, recur, or end up as a metastasising systemic disease. This underlines
the importance of a regular and consistent follow-up after treatment.