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10.14348/molcells.2015.0225

http://scihub22266oqcxt.onion/10.14348/molcells.2015.0225
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suck abstract from ncbi


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pmid26333275
      Mol+Cells 2015 ; 38 (9 ): 743-9
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  • Germline Modification and Engineering in Avian Species #MMPMID26333275
  • Lee HJ ; Lee HC ; Han JY
  • Mol Cells 2015[Sep]; 38 (9 ): 743-9 PMID26333275 show ga
  • Production of genome-edited animals using germline-competent cells and genetic modification tools has provided opportunities for investigation of biological mechanisms in various organisms. The recently reported programmed genome editing technology that can induce gene modification at a target locus in an efficient and precise manner facilitates establishment of animal models. In this regard, the demand for genome-edited avian species, which are some of the most suitable model animals due to their unique embryonic development, has also increased. Furthermore, germline chimera production through long-term culture of chicken primordial germ cells (PGCs) has facilitated research on production of genome-edited chickens. Thus, use of avian germline modification is promising for development of novel avian models for research of disease control and various biological mechanisms. Here, we discuss recent progress in genome modification technology in avian species and its applications and future strategies.
  • |*Animals, Genetically Modified [MESH]
  • |Animals [MESH]
  • |Cells, Cultured [MESH]
  • |Chick Embryo [MESH]
  • |Chickens/*genetics [MESH]
  • |Genetic Engineering/methods [MESH]
  • |Genome [MESH]
  • |Germ Cells/physiology [MESH]


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