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2015 ; 38
(9
): 743-9
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Germline Modification and Engineering in Avian Species
#MMPMID26333275
Lee HJ
; Lee HC
; Han JY
Mol Cells
2015[Sep]; 38
(9
): 743-9
PMID26333275
show ga
Production of genome-edited animals using germline-competent cells and genetic
modification tools has provided opportunities for investigation of biological
mechanisms in various organisms. The recently reported programmed genome editing
technology that can induce gene modification at a target locus in an efficient
and precise manner facilitates establishment of animal models. In this regard,
the demand for genome-edited avian species, which are some of the most suitable
model animals due to their unique embryonic development, has also increased.
Furthermore, germline chimera production through long-term culture of chicken
primordial germ cells (PGCs) has facilitated research on production of
genome-edited chickens. Thus, use of avian germline modification is promising for
development of novel avian models for research of disease control and various
biological mechanisms. Here, we discuss recent progress in genome modification
technology in avian species and its applications and future strategies.