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10.1038/nrg3116 http://scihub22266oqcxt.onion/10.1038/nrg3116 C4782217!4782217 !22179716     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22179716 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Genet 2011 ; 13 (1 ): 14-20 Nephropedia Template TP {{tp|p=22179716 |t=2011. Genomically humanized mice: technologies and promises |pdf=|usr=}}{{22179716 }} gab.com Text Genomically humanized mice: technologies and promises JO: Nat Rev Genet http://www.kidney.de/pget.php?&tw=1&pmid=22179716 #FOAvip Mouse models have become an invaluable tool for understanding human health and disease owing to our ability to manipulate the mouse genome exquisitely. Recent progress in genomic analysis has led to an increase in the number and type of disease-causing mutations detected and has also highlighted the importance of non-coding regions. As a result, there is increasing interest in creating 'genomically' humanized mouse models, in which entire human genomic loci are transferred into the mouse genome. The technical challenges towards achieving this aim are large but are starting to be tackled with success. Twit Text FOAVip Genomically humanized mice: technologies and promises ????Nat Rev Genet http://www.kidney.de/pget.php?&tw=1&pmid=22179716 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22179716 #FOAvip English Wikipedia <ref>{{Cite pmid|22179716 }}</ref> Genomically humanized mice: technologies and promises #MMPMID22179716 Devoy A ; Bunton-Stasyshyn RK ; Tybulewicz VL ; Smith AJ ; Fisher EM Nat Rev Genet 2011[Dec]; 13 (1 ): 14-20 PMID22179716 show ga Mouse models have become an invaluable tool for understanding human health and disease owing to our ability to manipulate the mouse genome exquisitely. Recent progress in genomic analysis has led to an increase in the number and type of disease-causing mutations detected and has also highlighted the importance of non-coding regions. As a result, there is increasing interest in creating 'genomically' humanized mouse models, in which entire human genomic loci are transferred into the mouse genome. The technical challenges towards achieving this aim are large but are starting to be tackled with success. |*Gene Transfer Techniques [MESH] |Animals [MESH] |Chromosomes, Artificial, Mammalian/*genetics [MESH] |Disease Models, Animal [MESH] |Gene Targeting/*methods [MESH] |Genetic Diseases, Inborn/genetics [MESH] |Genome-Wide Association Study/methods [MESH] |Humans [MESH] |Mice [MESH] |Mice, Transgenic/*genetics [MESH] |Promoter Regions, Genetic [MESH] |Recombination, Genetic [MESH] |Regulatory Elements, Transcriptional [MESH]Genomically humanized mice: technologies and promises (epmc).pdf DeepDyve Pubget Overpricing