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10.1542/peds.2016-3471

http://scihub22266oqcxt.onion/10.1542/peds.2016-3471
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suck abstract from ncbi


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pmid28255068
      Pediatrics 2017 ; 139 (4 ): ä
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  • Genomic Contraindications for Heart Transplantation #MMPMID28255068
  • Char DS ; Lázaro-Muñoz G ; Barnes A ; Magnus D ; Deem MJ ; Lantos JD
  • Pediatrics 2017[Apr]; 139 (4 ): ä PMID28255068 show ga
  • Genome sequencing raises new ethical challenges. Decoding the genome produces new forms of diagnostic and prognostic information; however, the information is often difficult to interpret. The connection between most genetic variants and their phenotypic manifestations is not understood. This scenario is particularly true for disorders that are not associated with an autosomal genetic variant. The analytic uncertainty is compounded by moral uncertainty about how, exactly, the results of genomic testing should influence clinical decisions. In this Ethics Rounds, we present a case in which genomic findings seemed to play a role in deciding whether a patient was to be listed as a transplant candidate. We then asked experts in bioethics and cardiology to discuss the implications of such decisions.
  • |*Bioethics [MESH]
  • |*Heart Transplantation [MESH]
  • |Child [MESH]
  • |Contraindications [MESH]
  • |Genetic Testing/*ethics [MESH]
  • |Genomics/*methods [MESH]
  • |Humans [MESH]
  • |Male [MESH]


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