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10.1186/s12711-016-0219-8 http://scihub22266oqcxt.onion/10.1186/s12711-016-0219-8 C4901500!4901500 !27286957     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27286957 &cmd=llinks): Failed to open stream: HTTP request failed! 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Genome-wide prediction using Bayesian additive regression trees |pdf=|usr=}}{{27286957 }} gab.com Text Genome-wide prediction using Bayesian additive regression trees JO: Genet Sel Evol http://www.kidney.de/pget.php?&tw=1&pmid=27286957 #FOAvip BACKGROUND: The goal of genome-wide prediction (GWP) is to predict phenotypes based on marker genotypes, often obtained through single nucleotide polymorphism (SNP) chips. The major problem with GWP is high-dimensional data from many thousands of SNPs scored on several thousands of individuals. A large number of methods have been developed for GWP, which are mostly parametric methods that assume statistical linearity and only additive genetic effects. The Bayesian additive regression trees (BART) method was recently proposed and is based on the sum of nonparametric regression trees with the priors being used to regularize the parameters. Each regression tree is based on a recursive binary partitioning of the predictor space that approximates an unknown function, which will automatically model nonlinearities within SNPs (dominance) and interactions between SNPs (epistasis). In this study, we introduced BART and compared its predictive performance with that of the LASSO, Bayesian LASSO (BLASSO), genomic best linear unbiased prediction (GBLUP), reproducing kernel Hilbert space (RKHS) regression and random forest (RF) methods. RESULTS: Tests on the QTLMAS2010 simulated data, which are mainly based on additive genetic effects, show that cross-validated optimization of BART provides a smaller prediction error than the RF, BLASSO, GBLUP and RKHS methods, and is almost as accurate as the LASSO method. If dominance and epistasis effects are added to the QTLMAS2010 data, the accuracy of BART relative to the other methods was increased. We also showed that BART can produce importance measures on the SNPs through variable inclusion proportions. In evaluations using real data on pigs, the prediction error was smaller with BART than with the other methods. CONCLUSIONS: BART was shown to be an accurate method for GWP, in which the regression trees guarantee a very sparse representation of additive and complex non-additive genetic effects. Moreover, the Markov chain Monte Carlo algorithm with Bayesian back-fitting provides a computationally efficient procedure that is suitable for high-dimensional genomic data. Twit Text FOAVip Genome-wide prediction using Bayesian additive regression trees ????Genet Sel Evol http://www.kidney.de/pget.php?&tw=1&pmid=27286957 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27286957 #FOAvip English Wikipedia <ref>{{Cite pmid|27286957 }}</ref> Genome-wide prediction using Bayesian additive regression trees #MMPMID27286957 Waldmann P Genet Sel Evol 2016[Jun]; 48 (1 ): 42 PMID27286957 show ga BACKGROUND: The goal of genome-wide prediction (GWP) is to predict phenotypes based on marker genotypes, often obtained through single nucleotide polymorphism (SNP) chips. The major problem with GWP is high-dimensional data from many thousands of SNPs scored on several thousands of individuals. A large number of methods have been developed for GWP, which are mostly parametric methods that assume statistical linearity and only additive genetic effects. The Bayesian additive regression trees (BART) method was recently proposed and is based on the sum of nonparametric regression trees with the priors being used to regularize the parameters. Each regression tree is based on a recursive binary partitioning of the predictor space that approximates an unknown function, which will automatically model nonlinearities within SNPs (dominance) and interactions between SNPs (epistasis). In this study, we introduced BART and compared its predictive performance with that of the LASSO, Bayesian LASSO (BLASSO), genomic best linear unbiased prediction (GBLUP), reproducing kernel Hilbert space (RKHS) regression and random forest (RF) methods. RESULTS: Tests on the QTLMAS2010 simulated data, which are mainly based on additive genetic effects, show that cross-validated optimization of BART provides a smaller prediction error than the RF, BLASSO, GBLUP and RKHS methods, and is almost as accurate as the LASSO method. If dominance and epistasis effects are added to the QTLMAS2010 data, the accuracy of BART relative to the other methods was increased. We also showed that BART can produce importance measures on the SNPs through variable inclusion proportions. In evaluations using real data on pigs, the prediction error was smaller with BART than with the other methods. CONCLUSIONS: BART was shown to be an accurate method for GWP, in which the regression trees guarantee a very sparse representation of additive and complex non-additive genetic effects. Moreover, the Markov chain Monte Carlo algorithm with Bayesian back-fitting provides a computationally efficient procedure that is suitable for high-dimensional genomic data. |*Algorithms [MESH] |*Genome-Wide Association Study [MESH] |Animals [MESH] |Bayes Theorem [MESH] |Breeding [MESH] |Genome [MESH] |Genomics/*methods [MESH] |Models, Statistical [MESH] |Phenotype [MESH] |Polymorphism, Single Nucleotide/*genetics [MESH] |Quantitative Trait, Heritable [MESH] |Selection, Genetic [MESH]Genome-wide prediction using Bayesian additive regression trees (epmc).pdf DeepDyve Pubget Overpricing